Rotavirus Essay - 717 Words

Every year it kills approximately 1 Million children world wide. The invader sneakes in unnoticed, takes over, all the while increasing in number as it goes. These children are falling victim to a rotavirus responsible for severe pediatric diarrhea. This rotavirus takes over in the human digestive tract, invading its cells and hijacking its protein synthesis machinery. This inhibits normal protein production in favor of a virus army. Children affected by this have had no chance of recovery, but now a glimmer of hope is visible on the horizon-a cure, whose secret lies in the virus unique structure-a tunnel, which, like the fate of the virus, could be sealed. So, what is the Rotavirus actually doing Our bodies consist of†¦show more content†¦Whereas normal RNA has a poly-A tail which triggers protein synthesis with a protein called PABP, the Rotavirus does not have these proteins. Instead, it uses a different protein called NSP3. What is being done about it? In order for researchers to begin to find a cure, they began looking at the structure of the viral protein and how the virus actually attaches itself to the host machinery. Researchers hoped that this knowledge would give them an idea of how the virus take-over could be prevented. The researchers used several different methods to determine the structure of the NSP3 protein. The method that yielded the most information was the Crystallographic Analysis. CRYSTALLOGRAPHIC ANALYSIS: This process allows the researchers to determine the structure of the viral protein bound to the virusmRNA. This is done by creating a crystal containing an array of ordered NSP3 proteins bound to RNA. X-rays are then shined on this co-crystal structure. The angles at which the light bounces off the atoms produce a diffraction pattern on a detector. From the positions of and intensities of the spots, dense areas of electrons are identified. These areas correspond the location of the atoms within the protein structure. What was determined Through Crystallographic Analysis, researchers were able to determine the structure of the viral NSP3 protein. The NSP3 protein isShow MoreRelatedEffectiveness Of The Rotavirus Vaccine Essay1878 Words   |  8 PagesEffectiveness of the rotavirus vaccine in New Zealand infants between 8 weeks and three years old Abstract Background. Rotavirus is a gastrointestinal illness characterized by vomiting, diarrhoea, stomach ache and a fever. Children less than three years old are particularly at risk of dehydration from the sudden vomiting and diarrhoea, which can require hospitalisation. 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RNA Extraction Kit RNA Extraction Kit Materials: †¢Ã¯â‚¬  Lysis Solution †¢Ã¯â‚¬  Washing Solution †¢Ã¯â‚¬  Sorbent †¢Ã¯â‚¬  RNA-eluentRead MoreList And Describe Several Pathogens That Can Cause Gastroenteritis Essay989 Words   |  4 Pages1. List and describe several pathogens that can cause gastroenteritis in children. - Rotavirus: is a common cause of gastroenteritis in infants and young children. Rotavirus is a non-enveloped, double-shelled virus with a double-stranded RNA genome. The virus is capable of infecting the epithelial cells of small intestine, leading to decrease in production of digestive enzymes and cell death. As a result of epithelial cells damage, the absorption of fluids by small intestine is interrupted whichRead MoreThe Effects Of Vaccination On Children And Children989 Words   |  4 Pagesdiseases children might experience is rotavirus which is major cause of severe acute gastroenteritis or AGE. 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